Application of Deep Eutectic Solvents in Formation of Carbon-Carbon and Carbon-Heteroatom Bond by Cross-Coupling Reactions

Deep eutectic solvents (DESs), known as the emerging organic reaction medium in the 21st century, have many advantages such as cheap, readily available, non-pollution, and biodegradable. Its good properties make it an alternative to volatile organic solvents. The insights in to carbon-carbon and carbon-heteroatom bond formations and their applications since 2017 are encapsulated, which not only highlighting the significant achievements pertaining to the important role of DESs as solvents but also including popular named organic reactions for cross-coupling reactions relating to the nature of DESs and the core optimum conditions. The review also encompasses a brief overview of the current situation and future development of DESs. Deep Eutectic Solvents are uniform liquid produced by mixing with two or more components at least containing a hydrogen bond acceptor and a hydrogen bond donor, which have many advantages of cheap, available, non-pollution, recyclable and biodegradable, so it is an effective alternative to volatile organic compounds and an excellent solvent for many chemical reactions.image