Two cases of viral re-suppression after M184V + R263 K selection on DTG/3TC without treatment modification.

Axel Ursenbach,Yvon Ruch,Baptiste Hoellinger,Anne Fuchs, Stéphanie Caspar, Frédérick Jegou,David Rey,Samira Fafi-Kremer,Thibault Mesplede,Pierre Gantner

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America（2024）

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摘要

DTG/3TC has a high genetic barrier against the development of HIV drug resistance. We report two cases of R263K + M184 V mutations during DTG/3TC failure followed by viral suppression after adherence intervention without treatment change that we attribute to residual drug activity, reduced viral fitness, and robust immune competence.

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