Hyperglycemia exacerbates cerebral ischemia/reperfusion injury by up-regulating autophagy through p53-Sesn2-AMPK pathway

Rui Wang, Meng Wang,Yu-Cheng Fan,Wen-Jun Wang,Deng-Hai Zhang,P. Andy Li,Jian-Zhong Zhang,Li Jing

Neuroscience Letters（2024）

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摘要

•Hyperglycemia aggravated cerebral injury by autophagy.•Hyperglycemia activated p53-Sesn2-AMPK pathway to upregulate autophagy.•ARI down-regulated p53 and P-p53ser15 to decrease autophagy.•ARI and 3-MA inhibited autophagy flux under hyperglycemia.

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关键词

Hyperglycemia,Autophagy,Ischemia/Reperfusion,Aldose reductase,P53,Adenosine monophosphate-activated protein kinase

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