Distinct Peripheral T-cell and NK-cell Profiles In HGBL-MYC/BCL2 versus DLBCL NOS Patients

A. Vera de Jonge, Carolien Duetz,Wassilis S.C. Bruins,Charlotte L.B.M. Korst,Rosa Rentenaar, Meliha Cosovic, Merve Eken, Inoka Twickler,Marcel Nijland,Marjolein W.M van der Poel,Koen de Heer,Clara P.W. Klerk, Leonie Strobbe,Margriet Oosterveld,Rinske Boersma,Harry R. Koene,Margaretha G.M. Roemer,Erik van Werkhoven,Martine E.D. Chamuleau,Tuna Mutis

Blood Advances（2024）

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摘要

•Distinct peripheral T-cell and NK-cell phenotypes in HGBL-MYC/BCL2 patients versus DLBCL, NOS patients without MYC rearrangements.•HGBL-MYC/BCL2 patients encompass exhausted PD-1+ T-cells without other immune effector cell impairments.

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