Piezo1 contributes to alveolar bone remodeling by activating β-catenin under compressive stress

Yukun Jiang,Hengyi lin,Yiling Chen,Yuanchen Lan,Han Wang,Tiancheng Li,Zhiai Hu,Shujuan Zou

American Journal of Orthodontics and Dentofacial Orthopedics（2024）

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摘要

•Compression force activated the Piezo1 channel in periodontal ligament cells (PDLCs).•Piezo1 regulates the osteogenic and osteoclastic activities of PDLCs under compression.•Piezo1 regulated the osteogenic differentiation of PDLCs via β-catenin under compression.•Piezo1 is critical for bone remodeling on the compressed side during tooth movement.

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