AmyloComp: A Bioinformatic Tool for Prediction of Amyloid Co-aggregation

Journal of molecular biology(2024)

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摘要
•Typically, the amyloid fibrils are homogeneous consisting of multiple copies of the same protein.•Recently, data has been accumulated on co-aggregation of different proteins in a common fibril.•We developed the first software enabling the prediction of protein co-aggregation in amyloid fibrils.•The method can be applied for the identification of microbial proteins capable triggering amyloidosis in humans.
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关键词
amyloids,computational method,co-aggregation,microbe-induced amyloidosis
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