Validity and value of metabolic connectivity in mouse models of β-amyloid and tauopathy

François Ruch,Johannes Gnörich,Karin Wind, Mara Köhler,Artem Zatcepin,Thomas Wiedemann, Franz-Joseph Gildehaus,Simon Lindner,Guido Boening,Barbara von Ungern-Sternberg,Leonie Beyer,Jochen Herms,Peter Bartenstein,Matthias Brendel,Florian Eckenweber

NeuroImage（2024）

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摘要

•Metabolic connectivity is a valid tool for observation of neuronal network changes.•MC shows significant functional connectivity loss in β-amyloid and tau mouse models.•MC reveals higher agreement with behavior compared to conventional µPET analysis.

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关键词

Alzheimer's disease,Metabolic connectivity,Amyloidosis,Tauopathy,Small-animal PET,Morris water maze

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