The role of neurosteroids in posttraumatic stress disorder and alcohol use disorder: A review of 10 years of clinical literature and treatment implications

MacKenzie R. Peltier,Terril L. Verplaetse,Margaret Altemus,Yasmin Zakiniaeiz,Elizabeth A. Ralevski,Yann S. Mineur,Ralitza Gueorguieva,Marina R. Picciotto,Kelly P. Cosgrove,Ismene Petrakis,Sherry A. McKee

Frontiers in neuroendocrinology（2024）

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摘要

•Neurosteroids are implicated in the underlying mechanisms of PTSD/AUD and are potential treatments.•Pregnenolone, progesterone & allopregnanolone have the most support for PTSD and AUD.•Few studies have explored the role of neurosteroids for PTSD and AUD concurrently.•There is an inconsistent application of SABV which warrants more rigorous research.

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neurosteroids,posttraumatic stress disorder,alcohol use disorder,sex as a biological variable

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