Hydroxyurea reduces infections in children with sickle cell anemia in Uganda

Ruth Namazzi,Caitlin Bond,Andrea L. Conroy,Dibyadyuti Datta,Abner Tagoola,Michael J. Goings, Jeong Hoon Jang,Russell E. Ware,Robert Opoka,Chandy C. John

Blood（2024）

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摘要

After starting hydroxyurea treatment, Ugandan children with sickle cell anemia had 60% less severe or invasive infections, including malaria, bacteremia, respiratory tract infections and gastroenteritis, than before starting hydroxyurea treatment (incidence rate ratio =0.40 [95% confidence interval], 0.29-0.54, P<0.001).

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关键词

Sickle cell anemia,hydroxyurea,infection,malaria,Africa

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