Mangiferin attenuates osteoporosis by inhibiting osteoblastic ferroptosis through Keap1/Nrf2/SLC7A11/GPX4 pathway

Xuehui Deng,Bingfeng Lin,Fang Wang,Pingcui Xu,Nani Wang

Phytomedicine（2024）

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摘要

•Mangiferin attenuates osteoporosis in ovariectomy or iron dextran-induced mice.•Mangiferin prevents ferroptosis in ovariectomy or iron dextran-induced mice.•Mangiferin inhibits ferroptosis in iron-dextran or erastin-induced osteoblasts.•Mangiferin activates SLC7A11/GPX4 pathway by directly bonding to Keap1.•Knockdown of Nrf2, SLC7A11 or GPX4 abolishes the protective effects of mangiferin.

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关键词

Osteoporosis,Mangiferin,Ferroptosis,SLC7A11,GPX4,Osteoblast

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