6-Gingerol ameliorates alveolar hypercoagulation and fibrinolytic inhibition in LPS-provoked ARDS via RUNX1/NF-κB signaling pathway

Qing Li,Chuan Xiao,JiaRun Gu,Xianjun Chen,Jia Yuan,Shuwen Li,Wei Li,Daixiu Gao,Lu Li,Ying liu,Feng Shen

International Immunopharmacology（2024）

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摘要

•Alveolar hypercoagulation and fibrinolysis inhibition are intimately associated with the refractory hypoxemia in ARDS but lacks effective drugs.•RUNX1/NF-κB signal pathway regulates alveolar coagulation and fibrinolysis inhibition.•6-Gingerol effectively ameliorates alveolar hypercoagulation and fibrinolysis inhibition in ARDS via RUNX1/NF-κB pathway.•6-Gingerol is expected to be new target in ARDS treatment.

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关键词

6-Gingerol,Alveolar hypercoagulation,Fibrinolytic inhibition,Acute respiratory distress syndrome,Runt-related transcription factor 1,NF-κB signaling pathway

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