Identification and characterization of a novel decalin derivative with anti- Candida activity from Streptomyces chrestomyceticus strain ADP4

A novel decalin derivative, trans-1-oxo-2,4-diacetylaminodecalin (1) with anti- Candida activity, had been isolated from Streptomyces chrestomyceticus strain ADP4. The structure of the compound was determined from the analysis of spectral data (LCMS/MS, UV, FTIR, 1D- and 2D-NMR). The anti- Candida activity of 1 was specific to Candida albicans and Candida auris . Further, it displayed inhibition of the early-stage biofilm of C. albicans . In-silico analysis of the compound revealed its drug likeness properties without any violations and PAINS alert when investigated for ADME properties . Along with the overall bioavailability, compound 1 did not show any predicted bioaccumulation and mutagenicity in the analysis by TEST software. Non-cytotoxic property was further confirmed by in-vitro assay on the HepG2 cell line.