Application of cell-free plasma next-generation sequencing technology in the diagnosis and management of pediatric meningitis

Nicole Duster,Nanda Ramchandar,Jennifer Foley,Lauge Farnaes,Nicole G. Coufal

JOURNAL OF MICROBIOLOGICAL METHODS（2024）

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摘要

This retrospective study evaluates the clinical utility of CFPNGS in the diagnosis and management of pediatric meningitis. CFPNGS identified a causative pathogen in 36% of 28 subjects, compared to 50% for diverse conventional testing (57% combined). CFPNGS may be considered as an adjunct to standard testing.

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关键词

Meningitis,CNS infection,Cell-free plasma sequencing,NGS,Metagenomics

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