Silver-catalyzed oxidative alkylation/alkynylation of 1,4-enynyl-3-ols with alkylbromides through radical 1,2-alkynyl migration

In this study, we have described a novel reaction between 1,4-enynyl-3-ols and alkyl bromides. The reaction was carried out in the presence of Ag2O, following a free radical 1,2-alkynyl migration pathway, which was confirmed through control experiments. This methodology offers several advantages, including high efficiency and a wide range of applicable substrates.