# Signal Processing in the Retina: Interpretable Graph Classifier to Predict Ganglion Cell Responses

IEEE OPEN JOURNAL OF SIGNAL PROCESSING（2024）

摘要

It is a popular hypothesis in neuroscience that ganglion cells in the retina are activated by selectively detecting visual features in an observed scene. While ganglion cell firings can be predicted via data-trained deep neural nets, the networks remain indecipherable, thus providing little understanding of the cells' underlying operations. To extract knowledge from the cell firings, in this paper we learn an interpretable graph-based classifier from data to predict the firings of ganglion cells in response to visual stimuli. Specifically, we learn a positive semi-definite (PSD) metric matrix M >= 0 that defines Mahalanobis distances between graph nodes (visual events) endowed with pre-computed feature vectors; the computed inter-node distances lead to edge weights and a combinatorial graph that is amenable to binary classification. Mathematically, we define the objective of metric matrix Moptimization using a graph adaptation of large margin nearest neighbor (LMNN), which is rewritten as a semi-definite programming (SDP) problem. We solveit efficiently via a fast approximation called Gershgor in disc perfect alignment (GDPA) linearization. The learned metric matrix M provides interpretability: important features are identified along M's diagonal, and their mutual relationships are inferred from off-diagonal terms. Our fast metric learning framework can be applied to other biological systems with pre-chosen features that require interpretation.

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关键词

Graph signal processing,interpretability,metric learning,retinal ganglion cell encoding,semi-definite programing

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