E. Coli LPS-induced calcium signaling regulates the expression of hypoxia-inducible factor 1α in periodontal ligament fibroblasts in a non-hypoxia-dependent manner

Xia Yang, Xuepei Cai,Jiayu Lin,Yifan Zheng, Zhihao Liao, Weiyin Lin, Xin He,Ying Zhang,XiaoHua Ren,Chufeng Liu

International Immunopharmacology（2024）

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摘要

HIF-1α-mediated metabolic reprogramming plays an emerging role in the regulation of early periodontal inflammation, but the underlying mechanisms remain to be fully understood. We report that Ca2+ activates HIF-1α transcription through the STAT3 signaling axis and stabilises HIF-1α via the ET-1 pathway during E. Coli LPS stimulation.

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关键词

Inflammation,Calcium signaling,Periodontal ligament,Hypoxia-inducible factor 1α,Glycolysis

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