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Phase III study of bilayer sustained-release tramadol tablets in patients with cancer pain: a double-blind parallel-group, non-inferiority study with immediate-release tramadol capsules as an active comparator

Masaharu Shinkai,Noriyuki Katsumata,Shinichi Kawai,Shoichi Kuyama,Osamu Sasaki,Yasuhiro Yanagita, Minoru Yoshida, Shima Uneda,Yasushi Tsuji,Hidenori Harada, Yasunori Nishida,Yasuhiro Sakamoto, Daisuke Himeji,Hitoshi Arioka,Kazuhiro Sato, Ryo Katsuki, Hiroki Shomura, Hideshi Nakano, Hideaki Ohtani, Kazutaka Sasaki,Takeshi Adachi

Supportive Care in Cancer（2023）

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摘要
We investigated whether twice-daily administration of a bilayer tablet formulation of tramadol (35
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关键词
Cancer pain,Tramadol,Sustained-release,Bilayer tablets,Randomized controlled study,Non-inferiority study
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