Identification of novel rare variants for anxiety: an exome-wide association study in the UK Biobank

Chuyu Pan,Shiqiang Cheng,Li Liu,Yujing Chen,Peilin Meng,Xuena Yang,Chun'e Li,Jingxi Zhang,Zhen Zhang,Huijie Zhang,Bolun Cheng,Yan Wen,Yumeng Jia,Feng Zhang

Progress in Neuro-Psychopharmacology and Biological Psychiatry（2024）

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摘要

•We investigated the rare variants for anxiety among 3738 European individuals with lower anxiety GWAS-derived polygenic risk.•Gene-based burden test revealed 11 candidate genes for anxiety, such as RNF123, DNAH2 and CCDC110.•Single variant association analysis detected 9 rare variants for anxiety, such as rs35726701(RNF123) and rs16942615(CAMTA2).

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关键词

Rare variants,Anxiety,Exome-wide association study,Protein-coding,7-item generalized anxiety disorder scale

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