Decitabine/paclitaxel co-delivery systems modified with anti-PD-L1 antibodies mediate chemoimmunotherapy for Triple negative breast cancer

Yang He,Qin Hu,Liting Wang,Chuanrong Chen

Materials & Design（2024）

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摘要

•Overexpressed DNMT1 drives PTX resistance and immune escape by EMT process in TNBC.•The combination of αPD-L1, DEX and PTX achieve a high quality synergistic anti-tumor effect.•DEC/PTX NPs@αPD-L1 achieve multiple tumor selection.•DEC/PTX NPs@αPD-L1 induced robust anti-tumor immunity via multilayered immunity effects.

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关键词

DNMT1,Immunotherapy,PD-L1,Co-delivery,Immunogenic cell death

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