Fluorinated thiazole–thiosemicarbazones hybrids as potential PPAR-γ agonist and α-amylase, α-glucosidase antagonists: Design, synthesis, in silico ADMET and docking studies and hypoglycemic evaluation

•2-(1-(2-((4-fluorophenyl)amino)−4-methylthiazol-5-yl)ethylidene)hydrazine-1-carbothioamide derivatives (3–6) was designed and synthesized.•The antidiabetic activities of the new thiazole-thiosemicarbazone hybrids were screened in vivo for blood glucose lowering activity.•Compounds 5 and 6 were found the most potent to inhibit α-amylase and α-glucosidase.•PPAR-γ agonist activity for compound 5 and compound 6 was assessed.•In silico ADMET and docking studies were performed.