Methylation of the Retrotransposon LINE-1 Subfamilies in Chorionic Villi of Miscarriages

S. A. Vasilyev, V. V. Demeneva, E. N. Tolmacheva, S. A. Filatova, A. S. Zuev, A. S. Ushakova,O. Yu. Vasilyeva, I. V. Lushnikov, E. A. Sazhenova, T. V. Nikitina,I. N. Lebedev

Russian Journal of Genetics（2023）

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摘要

Miscarriage is potentially associated with abnormal epigenetic regulation of genes responsible for the development of the embryo and placenta. The aim of this work was to analyze the methylation level of various subfamilies of the LINE-1 retrotransposon, which makes up about 17

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关键词

LINE-1 retrotransposon,DNA methylation,chorionic villi,miscarriage,aneuploidy,bisulfite sequencing,spontaneous abortions

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