Robustness of [18F]FDG PET/CT radiomic analysis in the setting of drug-induced cardiotoxicity

•Gray level discretization has a major impact on the repeatability of the radiomic features.•Voxel size demonstrated a non-dependency relationship with the repeatability of radiomic features.•Optimal methodology has led to the identification of potential early cardiotoxicity-related radiomic-based patterns.•Protocolized robustness analysis should be used prior to clinical studies involving radiomic data.