Meaning in life and Parkinson’s disease in the UK Biobank

•Meaning in life is an aspect of eudaimonic well-being associated with brain health.•In the large UK Biobank, meaning in life is associated with lower risk of incident PD over five years.•The association was independent of demographic, behavioral, clinical, and genetic risk factors.•The association generalized across age, sex, education, deprivation, and genetic risk.