Neutralizing Immunity Against Antigenically Advanced Omicron BA.5 in Children After SARS-CoV-2 Infection

Edward A. Belongia,Joshua G. Petrie, Leora R. Feldstein,Lizheng Guan,Peter J. Halfmann,Jennifer P. King,Gabriele Neumann,David Pattinson,Melissa A. Rolfes,Huong Q. Mclean,Yoshihiro Kawaoka

JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY（2024）

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摘要

We assessed serum neutralization of Omicron BA.5 in children following SARS-CoV-2 infection during the Delta or Omicron BA.1/BA.2 variant period. Convalescent BA.5 titers were higher following infections during the Omicron BA.1/BA.2 vs Delta variant period, and in vaccinated vs unvaccinated children. Titers against BA.5 did not differ by age group. We assessed serum neutralization against antigenically advanced Omicron BA.5 in children following SARS-CoV-2 infection with Delta and Omicron BA.1/2 variants. Post-infection titers to BA.5 were significantly higher for infections during the Omicron period and in vaccinated vs unvaccinated children.

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cross-neutralization,neutralizing antibodies,Omicron,SARS-CoV-2 infection

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