ProHap enables proteomic database generation accounting for population diversity

biorxiv(2024)

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摘要
Amid the advances in genomics, the availability of large reference panels of human haplotypes is key to account for human diversity within and across populations. However, mass spectrometry-based proteomics does not benefit from this information. To address this gap, we introduce ProHap, a python-based tool that constructs protein sequence databases from phased genotypes of reference panels. ProHap empowers researchers to account for haplotypic diversity in proteomic searches. ### Competing Interest Statement The authors have declared no competing interest.
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