Pseudo-craniotomy of a whole-brain model reveals tumor-induced alterations to neuronal dynamics in glioma patients

Brain tumors can induce pathological changes in neuronal dynamics both on a local and global level. Here, we use a whole-brain modeling approach to investigate these pathological alterations in neuronal activity. By fitting a Hopf whole-brain model to empirical functional connectivity, we demonstrate that phase correlations are largely determined by the ratio of interregional coupling strength and intraregional excitability. Furthermore, we observe considerable differences in interregional-versus-intraregional dynamics between glioma patients and healthy controls, both on an individual and population-based level. In particular, we show that local tumor pathology induces shifts in the global brain dynamics by promoting the contribution of interregional interactions. Our approach demonstrates that whole-brain models provide valuable insights for understanding glioma-associated alterations in functional connectivity. ### Competing Interest Statement The authors have declared no competing interest.