Microenvironment-responsive nanosystems for osteoarthritis therapy

•This review underscores the intricate nature of OA, and emphasizes the challenge of comprehending its pathogenesis which have hindered the development of targeted therapies and precision medicine for OA.•This review discusses the application of nanosystems in OA therapy, a field known as “OA nanomedicine”.•This review underscores the importance of further research to gain a comprehensive understanding of the molecular mechanisms through which nanosystems reprogram the OA microenvironment.