The multiscale topological organization of the functional brain network in adolescent PTSD

The experience of an extremely aversive event can produce enduring deleterious behavioral and neural consequences, among which posttraumatic stress disorder (PTSD) is a representative example. In this work, we aim to study the whole-cortex functional organization of adolescents with PTSD without the a priori selection of specific regions of interest or functional networks. To do so, we built on the network neuroscience framework and specifically on multisubject community analysis to study the functional connectivity of the brain. We show, across different topological scales (the number of communities composing the cortex), an increased coupling between regions belonging to unimodal (sensory) regions and a reduced coupling between transmodal (association) regions in the adolescent PTSD group. These results open up an intriguing possibility concerning an altered large-scale cortical organization in adolescent PTSD. ### Competing Interest Statement The authors have declared no competing interest.