Synthesis and In Silico Drug-Likeness Modeling of 5-FU/ASA Hybrids
Molbank(2023)
摘要
A series of 5-FU-ASA hybrids were synthesized with good yields using click chemistry as the key step. The structures of these compounds were elucidated by spectroscopic analysis. Finally, an optimal pharmacokinetic profile was also estimated for each synthetized hybrid. Taken together, hybrids 4a-h could be used as starting points for further pharmacological studies concerning therapeutic cancer intervention.
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关键词
5-FU,ASA,hybrid compounds,click chemistry,drug-likeness modeling
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