Palladium-Catalyzed Regioselective Synthesis of 2-SF₅-Indenols and Further Derivatizations

A palladium-catalyzed synthesis of 2-SF5-indenols has been developed by reacting commercially available boronic acid derivatives and readily accessible SF5-alkynes. The present methodology is fully regioselective thanks to the intrinsic polarization of SF5-alkynes. A selection of downstream functionalizations has been performed to highlight the versatility of 2-SF5-indenols and indenones as platforms for the design of more complex SF5-containing molecules.