Prussian blue-integrated porous β-TCP scaffolds for photothermal anti-tumor and NO-augmented osteogenesis

With the increasing attention paid to the recurrence of malignant bone tumors and bone defect repair have raised an urgent need of the advance of multifunctional therapeutic platforms for efficient tumor therapy and bone regeneration. This paper reports a multifunctional scaffold scheme by integrating prussian blue with S-nitrosothiol on DLP printed porous bioceramic scaffold (TPS). Near infrared triggered photothermal therapy can be used cooperatively for the treatment of local osteosarcoma. The release of Fe ions from the scaffold can promote bone regeneration, and the release of NO can further enhance the osteogenic effect. This study demonstrated the treatment of bone tumors and bone defect repair through TPS implantation. The characteristics of multifunctional scaffold, such as photothermal effect, release of NO and trace elements, provide a unique platform for simultaneous tumor treatment and bone defect repair.