ERK1/2-dependent activity of SOX9 is required for sublytic C5b-9-induced expression of FGF1, PDGFα, and TGF-β1 in rat Thy-1 nephritis

Zhijiao Wu,Zhiwei Zhang, Sicheng Zhou,Mengxiao Xie,Longfei Liu,Can Luo, Feixiang Zheng,Wen Qiu,Yingwei Wang,Jing Zhang

International Immunopharmacology（2024）

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摘要

•SOX9 transactivates FGF1, PDGFα, and TGF-β1 in C5b-9-attacked mesangial cells.•ERK1/2 phosphorylate SOX9, which enhances SOX9-mediated transactivation.•Inhibition ERK1/2 activation attenuates glomerular damage in Thy-1 nephritis.•Silencing ERK1/2 or SOX9 gene ameliorates glomerular injury in Thy-1 nephritis.

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关键词

Mesangial proliferative glomerulonephritis,Sublytic C5b-9,Phosphorylation,Growth factor,SOX9

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