Jet milling improves the polyphenol dissolution profile and biological activities of the hemp seed shell

The study aimed to investigate the impact of jet milling on the dissolution characteristics of hemp seed phenolic compounds. Three HSSP were prepared through grinding and sieving, while a superfine powder was obtained via jet milling. The superfine powder exhibited improved physicochemical properties, including a higher specific surface area, better dispersion, and wettability. These properties facilitated the penetration of solvents into the powder's structure, resulting in an optimal polyphenol dissolution profile and enhanced antioxidant activity. Furthermore, the polyphenol extract demonstrated significant protective effects against oxidative stress-induced damage in HUVEC cells, suggesting potential applications in the food and medicine industries. Overall, the study highlights the promising use of jet milling for producing powders with improved physicochemical and biological properties.