Extravascular Factor IX Pool Fed By Prophylaxis Is a True Hemostatic Barrier Against Bleeding

Alexandre Leuci,Nathalie Enjolras, Muriel Marano, Melanie Daniel, Marie Brevet,Philippe Connes,Yesim G. Dargaud

BLOOD（2023）

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摘要

Taken together, these results show that in individuals with severe hemophilia B receiving regular prophylaxis with FIX, extravascular accumulation of FIX over time may have a significant impact on the coagulation capacity and protection towards bleeding.

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关键词

collagen I,collagen IV,extravascular FIX,hemophilia B,joint,liver,saphenous vein bleeding model

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