Chronic heart failure with reduced EF: A decade of major pharmacological innovations

Background and objectives: Because of its severity, prevalence, and medical economic importance, heart failure is a chronic disease that is the subject of intense medical research. The aim of this article was to review the therapeutic innovations of the last decade that have been incorporated into the latest international recommendations for the treatment of heart failure. Method: Review of literature and current guidelines. Conclusion: The results of the clinical trials reviewed here represent major advances that will have a significant impact on quality of life, survival, rehospitalisation and, for certain treatments, a beneficial joint effect on commonly associated comorbidities such as diabetes and chronic renal failure. (c) 2023 Elsevier Masson SAS. All rights reserved.