Evolution of symptoms compatible with post-acute sequelae of SARS-CoV-2 (PASC) after Wild-type and/or Omicron BA.1 infection: A prospective healthcare worker cohort.

•Long COVID symptoms after Wild-type infection can persist over 18 months.•Primary or secondary Omicron infection did not increase long COVID risk.•COVID-19 vaccination before Omicron infection was not associated with long COVID.•A potential protective effect of physical/social activities should be further studied.