Golgi-triggered radiation sensitizer retention enhances the efferocytosis and immunotherapy in breast cancer with skeleton metastases

Radiotherapy with higher precision and better efficiency is required for breast cancer bone metastasis therapy. In this study, we synthesized a golgi-triggered radiation sensitizer, Furin Activated Iron Oxide nanoparticles (FAIOs), which could suppress breast cancer bone metastasis by targeting tumor micro-environment (TME) and enhancing immune response. As a multi-functional theranostic mediator, FAIOs enabled tumor-specific MRI and accurate radiation therapy in TMEs with enriched FURIN. The increased efferocytosis triggered by FAIOsmediated tumor cell apoptosis offered remarkable benefits. Moreover, the osteoclast-mediated bone destruction was markedly alleviated. These encouraging findings provided insights into therapeutic and diagnostic value of these multifunctional FAIOs for bone-metastatic breast cancer. (Scheme)