High angular sensitivity X-ray phase-contrast microtomography of soft-tissue through a two-directional beam-tracking synchrotron set-up
arxiv(2023)
摘要
Two-directional beam-tracking (2DBT) is a method for phase-contrast imaging
and tomography that uses an intensity modulator to structure the X-ray beam
into an array of independent circular beamlets that are resolved by a
high-resolution detector. It features isotropic spatial resolution, provides
two-dimensional phase sensitivity, and enables the three-dimensional
reconstructions of the refractive index decrement, $\delta$, and the
attenuation coefficient, $\mu$. In this work, we report on the angular
sensitivity and the spatial resolution of 2DBT images in a synchrotron-based
implementation. In its best configuration, we obtained angular sensitivities of
$\sim$20 $n$rad and spatial resolution of at least 6.25 $\mu$m in
phase-contrast images. We also demonstrate exemplar application to the
three-dimensional imaging of soft tissue samples, including a mouse liver and a
decellularised porcine dermis.
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