Evaluation of Archival HIV DNA in Brain and Lymphoid Tissues

Michelli F. Oliveira,Alec Pankow,Thomas Vollbrecht,Nikesh M. Kumar,Gemma Cabalero,Caroline Ignacio,Mitchell Zhao,Andrej Vitomirov,Ben Gouaux,Masato Nakawawa,Ben Murrell,Ronald J. Ellis,Sara Gianella

Journal of Virology（2023）

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摘要

HIV infection of the brain is associated with adverse neuropsychiatric outcomes, despite efficient antiretroviral treatment. HIV may persist in reservoirs in the brain and other tissues, which can seed virus replication if treatment is interrupted, representing a major challenge to cure HIV.

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archival archival dna

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