Reduction of Post-Infarct Ventricular Tachycardia by Transplantation of Transgenic Cardiac Fibroblasts

Maximilian Schiffer, E. Carls,Staffan Hildebrand, Jesús M. de la Fuente, M. A. Hesse,Caroline Geisen,Alexander Pfeifer, Farhad Bakhtiary, B. K. Fleischmann,Wilhelm Roell

Thoracic and Cardiovascular Surgeon（2023）

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摘要

Background: Loss of the gap junction protein connexin43 (Cx43) in the lesion area (IA) after myocardial infarction promotes the occurrence of ventricular tachycardia because (myo)fibroblasts (m)FB hardly express Cx43 and/or spike action potentials. To at least partially compensate this loss, we injected Cx43-(over)expressing cardiac FB into the IA and examined the effects on cardiac function and the incidence of ventricular tachycardia (VTi).

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关键词

transgenic cardiac fibroblasts,transplantation,post-infarct

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