The incidence and influencing factors of prolonged QTc interval in patients with HBV-ACLF.

Abstract Background Although a large number of studies have shown that QTc interphase prolongation is common in patients with cirrhosis, there are few studies on the relationship between QTc interphase prolongation and Acute-on-Chronic liver (ACLF) patients in China. In addition, the cause of liver failure that our country causes are different from abroad. This paper attempts to discuss the incidence and potential risk factors of QTc interphase prolongation of HBV-ACLF patients in China. Methods A retrospective analysis was performed on the clinical data of 206 HBV-ACLF patients admitted to our study from January 2016 to December 2021 and 94 healthy controls during the same period. The heart rate (HR) and QT interval of 12-lead electrocardiogram (ECG) of patients after admission were collected, and the corrected QTc interval was calculated by Bazett formula. According to the QTc interval > 440milliseconds, patients were divided into extended group. Results Among 206 HBV-ACLF patients, 68 cases (33%) showed prolonged QTc interval, which was significantly different from 3 cases (3.19%) in the healthy control group (P < 0.001). Univariate analysis showed that RBC, CHOL, CRE, K, FIB, Ascites, HBV-DNA and Child–Pugh class had statistical significance (P < 0.05), and binary logistic regression analysis showed that K, CRE, HBV-DNA and Ascites (P < 0.05) were the independent influencing factors for the prolonged QTc interval in HBV-ACLF patients. Conclusions In this study, it was found that the incidence of QTc interval prolongation was about 33% in HBV-ACLF patients. K, CRE, HBV-DNA and Ascites are independent factors influencing the prolonged QTc interval in patients with HBV-ACLF.