Neurological soft signs and social cognition in patients with schizophrenia: the missing link

Schizophrenia is a debilitating mental disorder characterised by a pro-nounced decline in mental, physical, and social functioning. Our study aims to investigate the relationship between the socio-cognitive and the subtle motor and sensory symptoms of schizophrenia, which are, respectively, represented by facial emotion recognition deficits (FERD) and neurological soft signs (NSS). Thus, we assessed 60 patients diagnosed with schizophrenia. FERD was mea-sured with the "Averaged Karolinska Directed Emotional Faces" set, and NSS was assessed with the Neurological Evaluation Scale. A strong and significant negative correlation was found between the NSS total score and the FERD total score (r = -0.7, p < 0.001). There was also a significant negative corre-lation between several of the subscores of both instruments. The results show that impaired social cognition is significantly associated with soft neurologi-cal disturbances in patients suffering from schizophrenia. Taken together, this reinforces the notion that schizophrenia is characterised by dysfunction and disconnection of a complex cerebral network, which can probably be influenced by psychosocial and physical nonpharmacological therapeutic interventions.