AB040. SOH23ABS_224. Oncological outcomes in total neoadjuvant chemotherapy comparative to standard neoadjuvant therapy in rectal cancer

Background: Total neoadjuvant therapy (TNT) is a new therapeutic strategy for locally advanced rectal cancer, whereby systemic neoadjuvant chemotherapy and concurrent chemoradiotherapy are delivered preoperatively. This may increase pathological downstaging and eradication of micro-metastases. There is little data on medium-term survival outcomes of TNT. This study aimed to determine differences in rates of local recurrence, disease-free and overall survival between patients receiving TNT vs. standard neoadjuvant chemoradiotherapy (nCRT).