The Role of Hyperglucagonemia in Diabetes Remission

Elena Lalama,Jiudan Zhang, Kilian Ruetther,Bettina Schuppelius, Marta Csanalosi,Stefan Kabisch, Nicolle Kränkel,Eicke Latz,Anette Christ,Domenico Tricò,Andrea Mari, A. Pfeiffer

Diabetologie Und Stoffwechsel（2023）

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摘要

Background Glucagon (GCG) plays an important role in the early development of diabetes by causing a feed-forward cycle of hyperinsulinemia and insulin resistance. The opposite view emphasizes that intra-islet alpha-beta-cell crosstalk is essential for intact insulin secretion and GCG determines hepatic fat oxidation, thus supporting intact metabolism. We investigated the role of GCG in diabetes remission within our “FAIR” study - Fasting-Associated Immune-metabolic Remission of Diabetes.

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hyperglucagonemia,diabetes,remission

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