Prospective changes in insulin response and cellularity of white adipose tissue following long-term weight loss

Background White adipose tissue (WAT) regulates a plethora of physiological processes, which require the interaction between multiple resident cell types. In insulin resistance/type 2 diabetes, and upon WAT remodeling by weight alterations, the cellular and spatial organization of WAT is drastically altered. However, the cell types governing these changes and their link to insulin sensitivity remain largely unexplored.