Isolation and characterization of spike S2-specific monoclonal antibodies with reactivity to pan-coronaviruses

Yabin Hu, Jun Chen, Jing Yang, Zhanpeng Liu,Xiaoyue Zhang,Qian Wu,Lulu Liu,Shishan Teng,Rongzhang He, Bo Liu,Xingyu Zheng, Rui Lu, Dong Pan, You Wang,Liting Peng,Hongying Chen,Yi-Ping Li,Wenpei Liu,Xiaowang Qu

VIROLOGICA SINICA（2024）

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摘要

•Five broad-spectrum mAbs identified from COVID-19 convalescents and vaccinees possessed the ability to recognize spike S2 of pan-coronaviruses.•Five mAbs targeted distinct but conserved epitopes on spike S2 of pan-coronaviruses.•Three of these five mAbs were competitively bound to the fusion peptide epitopes of coronavirus spike protein.

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