Chemical composition and biological activity of aerial parts of Salvia glutinosa L. growing in Georgia

A study of the chemical composition of the essential oil obtained from the aerial parts of Salvia glutinosa L., growing in Georgia, was carried out. The percentage of dominant components was determined by integration, the dominant component in the essential oil are caryophyllene oxide (11.43 %), spathulenol (5.93 %), humulene oxide (4.5 %). From terpene compounds oxygenated sesquiterpenes are dominants. The content of phenolic compounds was determined by using Folin-Ciocalteu reagent in the aqueous, methanol and chloroform fractions of the residual plant material. In aquaeous fraction total phenolic content is 25 ± 2 %, in methanolic fraction 26 ± 3 %, chloroformic - 1.8 ± 0.5 %. Fractions antioxidant and anti-inflammatory activity were determined. The methanolic fraction showed antioxidant activity in ORAC test (6 ± 2 micromole TE/mg), aquaeous fraction revealed antioxidant activity (0.61 ± 0.06 micromole TE/mg) using cell culture WS1. Methanolic fraction exhibited high anti-inflammatory activity, 100 % inhibition of NO production, at 52 μg/ml dose, without any significant toxicity