#2708 THE EFFECT OF PERCEIVED TEMPERATURE ON THE MORTALITY IN CHRONIC KIDNEY DISEASE PATIENTS

Abstract Background and Aims With the global warming, the interest in health risks from the high temperature exposure is growing. The perceived temperature is an equivalent temperature based on a complete heat budget model of the human body. We aimed to analyse the effect of perceived temperature on the overall mortality among patients with chronic kidney disease. Method A total of 32,870 patients with chronic kidney disease living in Seoul metropolitan region were recruited in a retrospective cohort (2001-2018). The perceived temperature during summer season (from July to September, at each year) was calculated using various climate factors including air temperature nearby automated weather station, dew point temperature, wind velocity, height of anemometer above ground, and total cloud amount. We assessed the association of perceived temperature using inverse distance weighting on mortality in patients with chronic kidney disease in the Cox proportional hazard model that was adjusted for sex, age, body mass index, estimated glomerular filtration rate, hypertension, and diabetes mellitus status. Results During the 6.14±3.96 years, 3,863 deaths (13%) were observed. We confirmed the significant effects of perceived temperature (average perceived temperature: hazard ratio [HR] 1.21, 95% confidence interval [CI] 1.18-1.23; minimum perceived temperature: HR 1.02, 95% CI 1.00-1.05; maximum perceived temperature: 1.20, 95% CI 1.18-1.22) on mortality among patients with chronic kidney disease in univariable analysis. In multivariable analysis, average perceived temperature (HR 1.22, 95% CI 1.19-1.25) and maximum perceived temperature (HR 1.20, 95% CI 1.17-1.23) showed increased risk for overall mortality among patients with chronic kidney disease. Conclusion Long-term exposure to high perceived temperature during summer season increased the risk of mortality among patients with chronic kidney disease.