Acute graft-versus-host disease after allogeneic stem cell transplantation from a haploidentical donor with post-transplant cyclophosphamide administration

Allogeneic hematopoietic stem cell transplantation is the only curative treatment for many life-threatening diseases. Due to the difficulty of finding an HLA-identical donor, transplantation from a haploidentical donor has become a frequent alternative. This option is associated with a higher risk of graft-versus-host disease (GVHD). In this article, we present the current view on the pathogenesis, treatment and prevention of GVHD and report a clinical case of acute GVHD after allogeneic hematopoietic stem cell transplantation from a haploidentical donor with post-transplant cyclophosphamide prophylaxis. The patient's parents gave consent to the use of their child's data, including photographs, for research purposes and in publications.