260. Aberrant Effective Connectivity During Eye Gaze Processing is Linked to Social Functioning in Schizophrenia

Abnormal gaze perception contributes to social dysfunction in schizophrenia (SZ). As we have previously shown (Tso et al., 2021), gaze perception is associated with aberrant effective connectivity in SZ. Here, in an independent sample, we used Dynamic Causal Modeling (DCM) to 1) determine whether gaze processing induces aberrant effective connectivity in SZ, and 2) reveal how aberrant connectivity contributes to social dysfunction and symptom severity.